Rabbit Antibodies Top Choice for Antibody Production

Posted by eliteinternet on February 23rd, 2021

This article provides information as to why rabbits are often the preferred host animal for custom polyclonal antibodies. Antibody production will always remain an essential part of research and experiments.  Rabbits are, in particular, a great source as an animal for those who generate antibodies for science.

Why rabbits?  It isn’t because of their little white fluffy tails!  There are plenty of animals from which to choose (mice, goats, sheep, etc.).  Rabbits, however, offer some unique traits that are actually really important when it comes to polyclonal antibody production.

The ability to generate polyclonal antibodies depends on the collection of B cells (in the blood or bone marrow). 

Rabbit antibodies offer an anatomical difference when compared to mice or rats.  In fact, rabbit antibodies provide a variety of advantages scientists adore.

For one reason or another, rabbits have super sensitive immune systems that can elicit robust responses to certain molecules (steroid hormones, lipids, glycolipids, etc.).  You aren’t likely to see cross-reactivity with non-targeted peptide sentences when you go with the rabbit.

Mice and rats, on the other hand, rabbits are not inbred, increasing population diversity – which is so important where antibodies and immune systems are concerned. 

When talking about stability, rabbit monoclonal antibodies offer a longer shelf life than even others.  Rabbits also offer disulfide bonds with their IgG heavy chain variable region.

From GCN2 Kinaseand LIMK1 to PBMC isolation and everything in-between, novel research antibody products are at your fingertips. 

Capralogics is here to help you with your upcoming projects.  With over two decades of experience, the team is efficient and ready to offer high-quality animal serum, plasma, and custom antibody services to professionals in industries related to medicine and research.