Finding the best CDMO for enhancing the permeation of gel formulations for better pain management

Posted by Akums Drugs & Pharmaceuticals Ltd on June 12th, 2023

Permeation of gel formulations: An Introduction

Permeation refers to the process by which a substance moves through a barrier, such as skin or a membrane. In the context of gel formulations, permeation refers to the ability of the gel to penetrate the skin or other tissues and deliver its active ingredients.

The permeation of a gel formulation is influenced by several factors, including the physicochemical properties of the gel, the nature of the skin or tissue being penetrated, and the characteristics of the active ingredients.

Some of the key factors that can affect the permeation of gel formulations include:

• Molecular weight and size of the active ingredient
• Solubility of the dynamic element in the lotion medium
• Gel viscosity and elasticity
• the pH of the gel formulation
• Skin hydration level and thickness
• Presence of enhancers or penetration agents in the gel formulation
• Duration and frequency of gel application

To assess the permeation of a gel formulation, various techniques or studies can be used. These studies can help to determine the efficacy of the gel formulation and optimize its formulation for improved permeation and delivery of the active ingredients.

Qualities of Best CDMO

Finding the best Contract Development and Manufacturing Organization (CDMO) to enhance the permeation of gel formulations for better pain management can be a crucial step in the success of any product. Here are some key factors to consider when searching for the right CDMO:

• Experience and Expertise: Look for a CDMO that has extensive experience and expertise in developing and manufacturing gel formulations. They should have a deep understanding of the science behind permeation enhancement and pain management, as well as knowledge of the regulatory landscape.
• Research and Development Capabilities: Choose a CDMO with strong research and development capabilities. They should have a track record of successfully developing novel gel formulations and improving their permeation properties.
• Technology and Equipment: The CDMO should have state-of-the-art technology and equipment to optimize gel formulation and manufacturing processes. This includes advanced analytical tools, equipment for permeation studies, and specialized manufacturing equipment.
• Quality Standards: Choose a CDMO that adheres to rigorous quality standards, such as Good Manufacturing Practices (GMP), to ensure the safety, efficacy, and consistency of your product.
• Regulatory Compliance: The CDMO should have a strong understanding of regulatory requirements and be able to navigate the regulatory landscape to obtain necessary approvals.
• Customization and Flexibility: Look for a CDMO that offers customization and flexibility in their services. They should be able to tailor their services to your specific needs and provide you with the level of support you require.
• Reputation and Track Record: Choose a CDMO with a solid reputation and track record of delivering high-quality services and products. Look for testimonials and case studies that demonstrate their expertise in gel formulations and permeation enhancement.

By considering these factors, one can find the best CDMO .A strong partnership with a reliable and experienced CDMO can help to optimize gel formulations, improve their permeation properties, and bring the  product to market successfully.

Akums Drugs and Pharmaceuticals Ltd.

The search for the best CDMO ends with Akums Drugs and Pharmaceuticals Ltd., which is a WHO -GMP certified CDMO, known to deliver the best and updated quality of pharmaceutical products. Dealing with difficult challenges and innovation never remains a constraint however for reference it can be observed that Akums’ Excederm expertise can improve the infiltration of diclofenac gel from 22 % to approx. 38 %. This permits better pain management. This reflects efficiency and proficiency.