How is ICSI treatment for infertility helpful to couples?

Posted by Hitesh on December 5th, 2020

A real revolution in the treatment of male infertility, intracytoplasmic sperm injection or ICSI is the latest one among the other ART techniques (Assisted reproductive technology) and it has proven its effectiveness with time.

Procedure for ICSI treatment for infertility

ICSI involves the injection of a single sperm into an oocyte. At the start, the woman receives medical treatment and a spermogram of the spouse (allowing the semen to be analyzed) is performed. The doctor then collects the gametes (mature oocytes and sperm). Biologists choose the most mobile spermatozoa, and of normal morphology, thanks to a large magnification under the microscope (X 500). Once this examination has been carried out, each sperm is micro-injected into an oocyte using a pipette. The operation is repeated for each fertilizable oocyte. Then the oocytes are cultured for the following steps continuing the procedure for ICSI treatment for infertility.

IVF with ICSI: How ICSI can help in infertility

Basically, these two techniques are similar in which fertilization takes place "in vitro ". In the case of conventional IVF , each oocyte is put into passive culture with 20,000 to 30,000 spermatozoa. Mobile sperm spontaneously come into contact with the oocyte, but only one of them will fertilize it.
Whereas, for the microinjection, oocyte does not require a few thousand sperms, it requires far less sperms than IVF. The biologist concentrates the most mobile forms, and then gives a micro-injection for each fertilizable oocyte.

ICSI treatment for infertility is a victory over male infertility

Yes! ICSI treatment for infertility is indeed a victory over male infertility; actually Top of Formit is a revolution in the treatment of male infertility. Now, when doctors detect a significant sperm anomaly, they can offer couples an oocyte micro-injection. The main advantage of this method is that it can be applied in the event of a much altered spermogram, where there are few mobile spermatozoa, or in even more extreme situations, in the total absence of sperm. In this case, the urologist takes them directly from the testicle, making a testicular biopsy. The sperm are then frozen in flakes. The most mobile are recovered after thawing, then one by one, micro-injected into each fertilizable oocyte.

Success rate of ICSI in male infertility-
The success rate of ICSI in male infertility is equivalent to that of IVF which is around 25-30%. But in the majority of cases, the success of these assisted reproductive technologies remains linked to age.

How ICSI can help in infertility and how it is a safe ART technique?

Risks associated with ICSI Infertility include-

It is indeed difficult to separate the increase in known risks (anomalies, chromosomal or morphological malformations) from the treatment itself and the population that is being treated.

Do some couples not have a higher risk of abnormalities, even in the case of spontaneous pregnancy? How to measure the exact impact of this technique? Factors like age, sperm problems probably have an impact in this procedure.
However, it is very likely that the ICSI technique is partly responsible for the increase in these malformations, which vary from 5.8% in the population of spontaneous pregnancies to 8.3% for pregnancies after micro-oocyte injection. Therefore, the doctor must inform couples about the risks associated with ICSI Infertility.

Less known and still underdeveloped, IMSI (Intra-cytoplasmic magnified sperm injection) is a technique for selecting sperm with very high magnification (X 5000). This process was developed by Israeli teams who came up with the idea of ​​making an even more subtle choice of sperm. The researchers achieved a magnification ten times greater than in a conventional ICSI. And in cases of infertility of male origin, it has been found that certain spermatozoa present abnormalities that are not visible after conventional magnification.
Logically, doctors deduced that the presence of these anomalies could reduce the chances of fertilization and therefore pregnancy. IMSI remains a complex technique that requires a lot of training and special care. Practiced in some countries today, it is reserved for couples who have encountered successive failures in their ICSI attempts or in certain cases of much altered sperm.

To know more about ICSI treatment for infertility, its need and risk, visit the best ivf specialist in udaipur, share your infertility problems and get the right solution.