Articles By kiko

Published 6 Months Ago
Unveiling Gene Isoforms by RNA Sequencing: Detection Methods and Applications
Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their codin

Published 6 Months Ago
The Molecular Microbiology of SARS-CoV-2: Detection Methods and Infection Mechanism
SARS-CoV-2 is a newly discovered human coronavirus group (HCoV), which are single-stranded RNA viruses belonging to the family of Coronaviridae. A range of respiratory diseases have been induced by some of these pathogens in the past. SARS-CoV-1 infected

Published 6 Months Ago
Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances
A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and more and more species, includ

Published 6 Months Ago
qPCR for SARS-CoV-2 Detection and Research: Introduction, Principles, and Applications
A highly delicate technique for the amplification and identification of deoxyribonucleic acid is polymerase chain reaction (PCR). In molecular biology, its conceptual simplification has made it the most utilized method and can, in theory, identify as litt

Published 6 Months Ago
RNA Splicing and How to Target It
RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing

Published 7 Months Ago
Differential Gene Expression (DGE) Analysis in RNA Sequencing
DEGs, or Differentially Expressed Genes, are genes whose expression levels show significant differences between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process by which information en

Published 7 Months Ago
Single-Cell RNA Sequencing in Drug Discovery and Development
One of the significant advantages of scRNA-seq in drug discovery is its impact on target identification. By allowing researchers to dissect complex tissues and diseases at the cellular level, scRNA-seq enables the identification of distinct cell subtypes

Published 7 Months Ago
What Is Microbiome and How to Study It
Microbiome, commonly confused with the term microbiota, is different from the latter as microbiota is defined as the microbial members of a microbiome. While the term microbiome does not only concern the microorganisms found in a specific environment but

Published 7 Months Ago
What Is the Difference Between Aerobes and Anaerobes?
Microorganisms, specifically bacteria, have been classified into several groups depending on different characteristics such as physical appearance, culture properties, energy and nutrient requirement, biosynthetic capacity, optimal growth temperature, oxy

Published 8 Months Ago
Analytical Approaches and Applications of Whole Exome Sequencing (WES) in Oncology
Genomics has revolutionized cancer research, transforming the way we diagnose, treat, and monitor cancer. Among the powerful genetic analysis methods, Whole Exome Sequencing (WES) stands out as a cutting-edge technique that employs sequence capture techno

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