Articles By kiko

Published 9 Months Ago
Amplicon Sequencing Technology Unveils the Enigmas of Microbial Populations
Amplicon sequencing is a cutting-edge technique that involves sequencing PCR products or captured fragments of specific lengths, enabling the analysis of sequence variations. Among the diverse applications of this technology, the 16S rRNA gene has emerged

Published 9 Months Ago
Application of Whole Plasmid Sequencing in Analyzing Drug Resistance Genes of Klebsiella pneumoniae
Klebsiella pneumoniae is a significant causative agent of hospital- and community-acquired infections, presenting with various clinical manifestations. Notably, the rapid spread of carbapenem-resistant K. pneumoniae (CRKP) has become a global threat, lead

Published 9 Months Ago
Analysis of Differential Gene Expression (DGE) in RNA Sequencing
Differentially Expressed Genes (DEGs) are genes that exhibit significant differences in expression levels between two or more conditions or experimental groups. In genetics and genomics research, gene expression refers to the process through which the inf

Published 9 Months Ago
Applications of Single-Cell RNA Sequencing in Drug Discovery and Development
Single-Cell RNA Sequencing (scRNA-seq) offers several advantages in drug discovery, primarily through target identification. By analyzing complex tissues and diseases at the cellular level, scRNA-seq allows researchers to identify distinct cell subtypes a

Published 9 Months Ago
Prokaryotic Microorganisms and Research Methods: Exploring the Tiny World
Prokaryotes, like eukaryotes, are organisms that store their genetic information in the form of deoxyribonucleic acid (DNA). However, prokaryotes differ from eukaryotes in that their genetic material is not enclosed within a membrane-bound organelle nucle

Published 9 Months Ago
Exploring the Diversity of Microbial Eukaryotes: Insights and Study Techniques
Living organisms are categorized based on various characteristics, and one classification system revolves around their cellular components, structure, and function. Consequently, organisms, including microorganisms, can be classified as either eukaryotes

Published 9 Months Ago
A Comprehensive Guide to De Novo Genome Assembly
Genome assembly stands as a pivotal objective in sequencing endeavors. De novo genome assembly, a prominent strategy in this field, involves reconstructing a novel genome from scratch without relying on any reference genomic data. It is an approach that a

Published 9 Months Ago
An Introduction to Amplicon Sequencing of 16S/18S/ITS Regions
Amplicon sequencing is a targeted approach that focuses on specific regions of DNA or RNA within a given sample. It involves amplifying and sequencing a particular gene or genomic region of interest. In the field of microbial ecology, the 16S rRNA gene is

Published 11 Months Ago
Applications of Targeted Region Sequencing in Human Disease Studies and Clinical Care
Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers

Published 11 Months Ago
The Methods of Whole Genome Sequencing
The emergence of whole genome sequencing technology is a revolutionary advancement in all areas of life sciences. Whole genome sequencing can detect variants, including single-nucleotide variants, insertions/deletions, copy number changes, and large scale

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