Antibody Drug Conjugates have shown effective results in the treatment of cancer

Posted by Sachin CMI on February 2nd, 2021

Antibody Drug Conjugates (ADC) are strong, selective antineoplastic agents that have been shown to be effective in the treatment of cancer and other malignancies. Antibodies can attack tumors from different angles by using a distinct mechanism of action. Most ADCs use soluble inhibitors which bind the receptor of the antigens and therefore inhibit its action. The inhibitors are usually selected based on their ability to selectively target one or more target molecules. This allows the use of many different chemical structures for achieving specific drug actions and more importantly achieving cytotoxicity.

Antibody Drug Conjugates (ADCs), like all other cytotoxic agents, are usually conjugated with DNA and RNA molecules. The DNA or RNA component is complementary to the target protein that has been identified as a prodrug in certain cases. The DNA or RNA binding is usually performed by enzymes called riboside conjugases. The major advantage of using DNA or RNA as DNA binding targets is that these biological systems are stable and do not undergo significant changes upon contact with biological probes. Hence, DNA or RNA binding is a high-throughput method for increasing the efficacy of anticancer medications. However, the use of DNA or RNA binding as target molecules for the purposes of administering chemotherapy as an agent in the form of Antibody Drug Conjugates can also lead to some serious consequences.

Read more @ https://www.linkedin.com/pulse/antibody-drug-conjugates-have-shown-effective-results-sachin-r