Urothelial Cancer Drugs Market– Statistics And Analysis & Forecast To 2023

Posted by Mrudula Anil Karmarkar on April 14th, 2021

The global urothelial cancer drugs market size is expected to reach USD 3.6 billion by 2023, as per a new report by Grand View Research, Inc., exhibiting a 22.9% CAGR during the forecast period. Availability of novel drugs, the presence of a strong pipeline, rising disease incidence, unhealthy lifestyle, and increasing awareness are driving this market.

Multiple therapeutic regimens are being followed across the globe in attempts to come up with a reliable treatment for Covid-19. One line of treatment includes the use of hydroxychloroquine, while a second treatment line focuses to use antiviral drugs used in the disease management of HIV. Both these approaches have surged demand from advanced antivirals and antimalarial drugs. This impacts the drug manufacturers as an off label indication for these drug classes has to be worked upon. At the moment, the WHO has not prescribed any of these approaches, neither they have commented if one is better than the other. The report will account for Covid19 as a key market contributor.

Urothelial cancer is the ninth most common malignancy in the world, with approximately 2.5 million patients and 420,000 newly diagnosed cases each year. Approximately 59% of bladder cancer cases occur in developed regions such as North America and Europe. The disease has the highest lifetime cost of care per patient among all tumors in the U.S. due to its high relapse rate and invasive lifelong monitoring including cystoscopy follow-ups.

Bladder transitional cell carcinoma (TCC) is the most common histology, accounting for nearly 90% of all urinary cancer cases. Urothelial cancer is clinically divided into three categories: non-muscle invasive bladder cancer (NMIBC, early-stage), muscle-invasive disease (MIBC, mid-stage), and metastatic disease (late-stage). At diagnosis, approximately 70% of cases are non-muscle invasive disease, 20% are at the muscle-invasive stage, and 10% are at the advanced stage.

Further key findings from the report suggest:

• The U.S. dominated the urothelial cancer market, with more than 60% of the market in 2017. Several factors such as the presence of a large target population increased adoption of novel therapeutics, and multiple product launches will drive the market in this region
• The therapeutic landscape is expected to witness a paradigm shift toward combination therapies and novel immuno-oncology products. Combination regimens, particularly checkpoint inhibitors, are likely to be introduced in the first-line setting. Immune checkpoint blockade therapy is expected to replace the current standard of care in bladder cancer in the foreseeable future
• Therapeutic development in the second-line setting for chemotherapy-intolerant patients is expected to have a major impact in the urothelial cancer space
• Urothelial cancer presents a strong opportunity for introducing first-in-class treatments due to high unmet needs. Opportunities remain in the non-muscle invasive bladder cancer (NMIBC) setting where there exists an unmet need for treatment options for patients who are BCG-intolerant or ineligible
• Some of the key players operating in this market are Roche, Merck, Bristol-Myers Squibb, AstraZeneca, and Pfizer.

Urothelial carcinoma or transitional cell carcinoma is a malignant neoplasm occurring from urothelium. The disease is the ninth most common malignancy in the world, with approximately 2.5 million patients and 420,000 newly diagnosed cases each year. Bladder transitional cell carcinoma (TCC) accounted for approximately 90% of all urinary cancer cases.

Urothelial cancer is clinically divided into three categories: non-muscle invasive bladder cancer (NMIBC, early-stage), muscle-invasive disease (MIBC, mid-stage), and metastatic disease (late-stage). At diagnosis, approximately 70% of cases are non-muscle invasive disease, 20% are at the muscle-invasive stage, and 10% at the advanced stage.

Approximately 59% of bladder cancer cases occur in developed regions such as North America and Europe. The economic and human toll of urothelial cancer represents a highly disproportionate health burden.  The disease has the highest lifetime cost of care per patient among all tumors in the U.S. due to its high relapse rate and invasive lifelong monitoring including cystoscopy follow-ups.

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Some of the key players operating in this market are Roche, Merck, Bristol-Myers Squibb, AstraZeneca, and Pfizer. Collaborations for development, broader product portfolios, and regional expansion in emerging markets are key strategic undertakings of these companies to increase their market share. The market is expected to grow increasingly crowded with several product launches during the forecast period.

Merck and AstraZeneca are expected to lead the market in 2023, supported by approvals of (Imfinzi + tremelimumab) and (Keytruda + chemotherapy) regimens in early lines of treatment for both chemo-ineligible and chemo-eligible patients. It is expected that immune checkpoint blockade therapy could replace the current standard of care in bladder cancer.

Grand View Research has segmented the global urothelial cancer drugs market based on treatment class and country:

Urothelial Cancer Drugs Treatment Class Outlook (USD Million, 2017 - 2023)

• Chemotherapy
• Immunotherapy

Urothelial Cancer Drugs Country Outlook (USD Million, 2017 - 2023)

• The U.S.
• The U.K.
• France
• Germany
• Italy
• Spain
• Japan

About Grand View Research

Grand View Research, Inc. is a U.S. based market research and consulting company, registered in the State of California and headquartered in San Francisco. The company provides syndicated research reports, customized research reports, and consulting services. To help clients make informed business decisions, we offer market intelligence studies ensuring relevant and fact-based research across a range of industries, from technology to chemicals, materials and healthcare.

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