Infliximab ? An effective anti- TNF drug for IBD treatment

Posted by Daniel Disusa on October 5th, 2015

Popularly known by the brand name Remicade, infliximab for inflammatory bowel disease treatment is recommended for patients who suffer from moderate to severe conditions and have to combat active and life-threatening fistulising of intestines. Infliximab is recommended when the preliminary set of drugs fail to supress chronic gastrointestinal inflammation and IBD symptoms. A widely used biologic medication or anti-TNF drug for inflammatory bowel disease therapies, infliximab targets a specific protein named TNF alpha, and eventually surpass its abnormal responses. In normal cases TNF alpha is naturally developed to fight infections. This might lead to temporary inflammation that often gets supressed soon. However, overproduction of TNF alpha can cause major and lasting inflammation in the affected areas. Infliximab regulates the actions of TNF alpha, relive the symptoms and prevent gastrointestinal inflammation. Unlike the other IBD treatments that are currently recommended, infliximab therapies ensure lasting results within a few weeks of initiation of the first set of treatment.

An effective drug that most of the IBD patients rely on, infliximab is mostly available in power form. That said, it can be converted into liquid and later administered through intravenous infusions. Infliximab can never be given in the form of tablets as it might result in major alterations in the normal functions of the digestive system. Intravenous infusions of infliximab is normally conducted amid the presence of an experienced doctor or a specialist nurse. Although these intravenous infusions often take about two hours, some clinics make use of faster infusion methods that lessen the time required for the completion of the therapy. That said, on an average, an IBD patient has to undergo nearly five to six infliximab therapies to achieve long-term remission. Although the amount of infliximab administered depends on the weight of the patient, 5mg/kg is the normally recommended dosage. Paracetamol, antihistamine or hydrocortisone are given prior to infliximab therapies, as they help minimise risks and side effects.


More information can be obtained on a bespoke social networking website, developed solely for gastroenterologists around the world. GI health care experts who specialize in GI disorders can register with The Gut People and start interacting with top GI experts around the world, on various commonly found gastrointestinal disorders like inflammatory bowel disease and intestinal tuberculosis. The Gut People is also equipped with unique functionalities that help download informative documents on gastrointestinal disorders, as well as their comprehensive diagnosis steps and advance treatment methods.

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Daniel Disusa

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Daniel Disusa
Joined: August 13th, 2015
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