Uric Acid In Blood: Causes And TroublesPosted by Carver Lundgren on May 27th, 2021 Now-a-days, those people, who're health conscious and go for regular health check- up, are acquainted with the term "uric acid ".But many don't know what it really is and what types of problems it may create in the torso if it has excess of that acid. What is uric acid? From the nucleic acid of the living cells, by different metabolic processes, two substances called adenine and guanine are produced which are known as purine. An enzyme in our body called xanthine-oxidase converts this purine, in three stages, to uric acid. Chemically, it is composed of carbon, nitrogen, hydrogen and oxygen whose formula is C5H4N4O3. The salt of it is known as sodium urate monohydrate. Once the decay of cells occurs at an interest rate greater compared to the normal rate, then the synthesis of uric acid in the torso also increases. The most permissible amount of it in the blood of a grown-up male is 8mg/100ml of blood while that in an adult female is 6mg/100ml of blood. If its level in the blood is significantly more than the aforementioned maximum level, then it is known as hyper-uricaemia, which is not a normal condition. It sometimes appears that generally its level in the blood increases gradually after 20 years and in case of females this occurs, particularly, after the menopause. The total content of the acid in the blood may remain within 900mg - 1200mg with regards to the bodyweight, food habit and racial difference. 75% of it in our blood is excreted, unchanged, through urine, while 20 - 25% of it, changed somewhat, is excreted through the faeces. Uric acid in our blood is in the form of monosodium urate, which, if increases, gets deposited in the joints and kidneys and causes diseases. So how exactly does hyper-uricaemia occur? Hyper-uricaemia may occur because of one or more of the next reasons: 1) Increased formation of uric acid because of genetic characteristics or metabolic malfunctioning of enzymes. 2) Chronic kidney disease ultimately causing less excretion of the acid through urine. 3) A lot of intake of meat (lamb, beef) or sea-fishes. 4) Eating of fructose-rich foods. Sugar contains about 50% fructose. 5) Drinking of corn syrup. 6) Diseases causing rapid cell turnover, like polycythaemia, several types of leukaemia and a skin disease called psoriasis. 7) Drinking too much alcohol, particularly, beer. 8) Daily intake of suprisingly low dose of aspirin. Axit Uric of tea or medicine containing caffein. 9) Thiazide like medicines which are accustomed to treat blood pressure and dropsy. 10) Medicines like pyrazinamide and ithambutol which are accustomed to treat tuberculosis. 11) Medicines like livodopa, methyldopa, cysplatin and cyclomerine. 12) When an obese person tries to lose weight quickly, then there occurs a growth in the uric acid level in his/her blood. 13) While doing excessive physical work or exercise, there is an elevated formation of lactic acid in the body. At that time, there may be a temporary increased production of uric acid in the blood. 14) Type 2 diabetes, high blood pressure, obesity, insulin-resistant disease syndrome'x'- in all these cases the degree of the acid is high. Problems caused by high uric acid level in blood This may cause mainly 2 forms of diseases -- 1) Gout 2) Uric acid stone in kidneys Gout Gout arthritis is produced by increased uric acid level in the blood brought on by any disturbance in your body's purine or protein metabolism. Uric acid doesn't dissolve properly inside our blood. So, any excess of it in the blood gets deposited in our joints in the form of monosodium urate crystals and causes inflammation. Gout is a very painful disease of joints, which mainly occurs to aged persons. Males are 5-7 times more susceptible to this disease compared to females. The issue starts when the total amount of uric acid in the blood crosses its normal amount of 2-7mg/100ml. It is seen that the painful apparent symptoms of gout arthritis start showing if this level in the event of females exceeds 3.5-5mg/100ml and in the event of males 5-7mg/100ml. Again, in the event of severe gout, the particular level may be 20mg/100ml or more. Uric acid stone in kidneys When the total amount of uric acid in the blood is quite high, then the surplus amount after saturation, which doesn't dissolve in blood, starts depositing in the kidneys, since 75% of the acid is excreted from the human body through the kidneys. When the result of urine is acidic, then a kidneys cannot throw out the complete of uric acid through urine. Moreover, during summer, when your body loses lot of water or those people, who drink very less volume of water, for them there's a chance of easily developing stone in the kidneys. You can not feel any trouble at the first stage of kidney stone. Even, it can't be detected by ordinary X-ray or scan because the urate stone is radiolucent. It could be detected by sonography only.Like it? Share it! More by this author |