Use Of Topical Formulation Development in the Pharmaceutical Industry

Posted by TergusPharma on June 19th, 2021

Topical formulation development is used for the product, primarily drug development. These drugs can treat systemic and local indications of the disease for the treatment. They also facilitate patient compliance, ease the delivery, and avoid the first passes metabolism problems. The topic formulations can be in cream, liquid, semisolid, or gel forms. Successful development of the topical formulation needs physicochemical properties understanding, including the release characteristics, vehicle nature of the drug delivery, and drug delivery system composition. 

Additionally, organoleptic properties like feel, scent, and appearance are also significant. For process manufacturing and semisolid drug dosage development, you require implementing the CMC strategies delivering chemical, physical and efficacy stability, and process impurities minimization. Different pharmaceutical companies handle the production process of the topical formulation Development well due to the presence of a well-skilled team, advanced equipment to manufacture the most complex topical formulations.

Different methods to determine the development of topical formulation

Various companies include the capacity to test, formulate, and develop topical drugs or products. Some of the methods for the formulation of topical drugs are as below.

• In Vitro Permeation test (IVPT) and In Vitro Release Testing (IVRT)
• Development of novel formulation
• Optimization of the existing formulation
• Controlled substances
• Optimization and recognition of the significant process parameters implementing DEO when appropriate
• Low and High shear homogenization
• Implementation and development of the process controls 
• Mixing through variable speed
• Temperature control
• Granulation and blending
• Trials of the new drugs or products
• Double-sided agitations

The efficacy and stability of the drugs for the formulation of the topical development are dependent on various factors like mixing time and method, cooling and heating rate, the order in which the ingredients are added, and temperature. Remember, there are also specific ingredients getting compromised due to natural aspects like oxygen and UV light. So, it is necessary to develop a topical formulation preventing these problems and will make sure that the drug is effective and safe to launch in the market.

 Also, Read our exclusive blog on How Topical formulation development in the pharmaceutical industry is Booming