Researchers Prepared New Tools for the Production of Exosome Drug CarriersPosted by beauty33 on October 27th, 2021 Recently, Yang Hui, a researcher at Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, developed a nanofluidic chip technology to achieve high-throughput preparation of exosome drug carriers and experimentally verify the anti-tumor effect of novel exosome drug carriers. Exosomes are nanoscale particles that can be secreted into the extracellular space or body fluids by almost all cell types, with a diameter of approximately 30–200 nm. As a natural intercellular substance carrier, they achieve intercellular communication through the transfer and transmission of biomolecules and have been used as natural delivery carriers for drug molecules for the treatment of human diseases, with application potential in the field of intelligent drug delivery.
In the study, the clinically approved anti-tumor drug doxorubicin was selected as the validation object, which confirmed that the \"exosome nanoperforator\" could efficiently load it into the exosome, and the drug-loaded exosome could transport doxorubicin into lung cancer cells and tumor spheres, induce cancer cell death and inhibit tumor sphere growth. The results show that the developed nanoliter chip ensures the activity of drug-containing exosomes and can release the contained drugs without producing immune response, which is an important prerequisite for the clinical application of exosomes drugs. Collected by Creative Biostructure, a world leading biotech company specialized in structural biology. Now scientists at Creative Biostructure have successfully developed exosome/microvesicle products derived from different sources, which have diverse applications in exosome-based research, reflecting the functional status of their parent cells. Its range of products includes exosomes isolated from cancer cell lines, exosomes isolated from stem cell lines, exosomes isolated from immune-related cell lines, exosomes isolated from general cell lines, exosomes isolated from body fluids, fluorescent exosomes/microvesicles, as well as lyophilized microvesicles. Like it? Share it!More by this author |