What Causes Alzheimer's Disease? Scientists Are Giving Different Answers

Posted by beauty33 on January 25th, 2022

Globally, approximately 7 million people are newly diagnosed with Alzheimer\'s disease each year, and they desperately need new treatments to slow the progression of the disease. Despite decades of research, there is still no cure for Alzheimer\'s disease, and this is largely because the cause of the disease\'s development is still uncertain. Various aspects of the cause have been studied, but none have been conclusively proven. This article describes three main lines of research: amyloid precursor protein (APP), autoimmune antibodies, and bacterial or viral infection.

Alzheimer\'s disease was named after the German neuropathologist Alois Alzheimer, who in 1906 noticed \"clumps of filaments between the nerve cells\" in the brain of Auguste Deter, a 55-year-old German woman suffering from memory loss, speech problems, and strange behavior. This is the beginning of the research on APP which claims that tau protein and beta amyloid (Aβ) form tangles and plaques that cause brain cell death and brain shrinkage, which can lead to memory loss, personality changes, and an inability to care for oneself.

This hypothesis has inspired numerous drug trials aimed at breaking down these toxic proteins. However, most of these trials have yielded disappointing results and have not produced expected improvements in patients.

On the other hand, some scientists believe that the culprits of Alzheimer\'s disease are common viruses and bacteria, which may eventually cause neurological death by long-term infiltration of the human brain, leading to irreversible deterioration of cognitive ability and memory.

So far, there are some indications that SARS-CoV-2 infections may lead to neurological damage. For example, a report presented at a recent academic conference of the Alzheimer\'s Association analyzed blood samples from recovered patients with COVID-19 and found elevated levels of the chemical markers that commonly accompany the onset of Alzheimer\'s disease in these blood samples.

In a new report, researchers from Mount Sinai Hospital in Toronto, Canada, suggest that Alzheimer\'s disease may be an autoimmune disorder. Autoimmune diseases, which include a range of disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), occur when the body\'s immune defense system attacks healthy cells.

The new study, published in May 2021 in The Journal of Applied Laboratory Medicine, JALM, found that specific autoantibodies were found in the cerebrospinal fluid of people with Alzheimer\'s disease. This adds to the evidence suggesting that Alzheimer\'s disease may be an autoimmune disease.

The authors of the study concluded that disruptions of the blood-brain barrier (BBB) typically prevent some molecules from being exchanged between the brain and the circulatory system, which may contribute to Alzheimer\'s disease. For example, it has been observed that athletes who are susceptible to traumatic brain injury have an increased chance of developing Alzheimer\'s disease. In any case, however, any damage to the BBB can actually open the door for these immune cells to enter brain tissue and further accelerate the destruction of certain neuronal cells, which may be the cause of Alzheimer\'s disease.

As a reliable service provider in the scientific research industry, Creative Biolabs has a good reputation and significant knowledge in natural autoantibody (NAA)-related neurological disease, particularly in Alzheimer\'s disease. Based on years of research experience in Alzheimer\'s disease and first-in-class technologies, Creative Biolabs provides a wide range of products and services for NAA associated Alzheimer\'s disease studies.

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