Find Out More About Microbial Fermentation Technology Market Global Growth With Rising CAGR And Forecast Till 2030

Posted by Mrudula Anil Karmarkar on March 21st, 2023

The global microbial fermentation technology market size is expected to reach USD 49.39 billion by 2030, registering a CAGR of 5.8% according to a new report by Grand View Research, Inc. Since fermentation is observed to be of utmost importance in the manufacturing of biopharmaceuticals, there is also a growing demand for microbial fermentation technology in biopharmaceutical manufacturing. This has led to increasing collaborations and developments in this market space.

For instance, in September 2021, BIOVECTRA and ABEC collaboratively announced that the latter company would provide CSR single-use microbial fermentation solutions to expand BIOVECTRA’s manufacturing capabilities. The newly installed solutions are expected to provide a faster turnaround time with high-growth microbial fermentation on large scale. Moreover, in September 2022, Cargill and Genomatica along with Cyclone Engineers are working on a project to scale up the bioreactor fermentation processing. This project is a part of the National Biotechnology and Biomanufacturing Initiative with a grant of USD 2.5 million.

Furthermore, technological advances in microbial fermentation platforms are also expected to supplement the market growth. For instance, several metabolic engineering approaches have been developed by researchers to enhance the performance of microbial cell factories used for the production of complex biologics or small molecules. Such continuous developments in this market space are likely to increase the adoption of this technology in biomanufacturing.

Additionally, various medications and vaccines, such as hormones, antibody fragments, and pneumococcal vaccines, are bio-manufactured using microbial fermentation techniques. Bacterial cells are often resistant to shear damage, enabling the use of high-shear radial impeller systems and high agitation rates. This gives the fermentors a high mass transfer potential, allowing them to accommodate fast metabolizing, high-cell density microbial cell cultivations and increasing the quantity of product that the bioprocesses can produce. Thus, with the increasing adoption of SUB fermentors for bacterial fermentation, the market is likely to witness significant growth in the coming years.

The factors such as increasing demand for biologics, development of innovative therapies based on smaller biologic drug substances, and advancements in microbial fermentation platforms/ technologies have driven the growth of the industry in recent years. In the past few years, the microbial fermentation space is witnessing an upsurge in demand owing to the exponential growth in the microbial biopharmaceutical industry. The advantages offered by microbial expression systems such as short-development timelines, higher expression levels, and less media cost as compared to mammalian cell culture have majorly contributed to the resurgence in interest in using microbial organisms in manufacturing processes. Overall, microbial fermentation technology offers higher yields, faster development, better scalability, reduced variation between batches along with lower production costs.

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Amidst the COVID-19 pandemic, the microbial fermentation technology market was relatively less impacted. The surge in demand for various biologics resulted in growing attention toward microbial biotechnology. Market players involved in COVID-19 vaccine development and manufacturing have also relied on microbial expression systems for vaccine development. For instance, the Pfizer-BioNTech vaccine is based on bacterial fermentation for the production of DNA plasmids required for vaccine manufacturing.

Furthermore, increasing demand for microbial contract manufacturing services is anticipated to supplement the market growth. Currently, more than 115 industry participants are actively engaged in offering microbial fermentation services. Thus, the market is highly fragmented with the presence of well-established players such as AbbVie Contract Manufacturing, Lonza, and others. Such a high number of service providers in this market space are likely to spur market growth in the coming years.

Microbial Fermentation Technology Market Report Highlights

  • Based on application, the antibiotics segment captured the highest market revenue share in 2021. Increasing research activities due to the rise of antibiotic-resistant microbes have positively impacted market growth
  • Owing to the faster and more stable growth pattern of microorganisms, the use of fermentation in small molecule synthesis is expected to witness lucrative growth throughout the forecast period
  • By end-users, CMOs and CDMOs accounted for a significant share in 2021. The capacity expansion by several CMOs and the growing trend of outsourcing is expected to propel the segment revenue generation
  • Asia Pacific dominated the market in 2021 owing to the high number of operating CMOs and the growing biopharmaceutical industry in countries such as India, Japan, and China
  • Furthermore, the demand for biologics and biopharmaceuticals is increasing in Japan. As a result, Japanese firms are undertaking various strategic initiatives to enhance their domestic biomanufacturing operations
  • North America is anticipated to witness the fastest growth throughout the forecast period owing to the presence of a well-established biopharmaceutical industry coupled with a high number of fermentation solution providers
  • Continuous efforts by key players to improve their product offerings are also contributing to North America’s regional market growth

Furthermore, yeasts are a commonly used eukaryotic host for the production of heterologous proteins and provide several advantages in the manufacturing of therapeutic recombinants. The use of yeast as a cell factory has various advantages, including simplicity of genetic manipulation, high cell density development, and post-translational modification possibilities. Thus, the rising focus of various research institutes and scientists on exploring the potential of yeast cells in therapeutic or clinical applications will expedite market growth in the near future.

At the same time, owing to the COVID-19 pandemic, the urgent need for the development of a vaccine against the SARS-CoV-2 virus resulted in the high usage of fermentation technology in research and development. For instance, in a study published in March 2021, a team of researchers used bacterial fermentation technology for the large-scale and inexpensive production of the COVID-19 vaccine. Such advancements are anticipated to increase the use of microbial fermentation in the coming years.

List of Key Players in Microbial Fermentation Technology Market

  • Biocon Ltd.
  • BioVectra Inc.
  • Danone UK
  • F. Hoffmann-La Roche AG
  • Koninklijke DSM NV
  • Lonza
  • Novozymes A/S
  • TerraVia Holdings, Inc.

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Mrudula Anil Karmarkar

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Mrudula Anil Karmarkar
Joined: July 2nd, 2020
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