Some Benefits of VitaPulsePosted by VitaPulse Benefits on August 17th, 2016 A large number of published data shows that the levels of mitochondrial vitapulse superoxide production correlate with the rate of aging of the different species (106-115). According to recent data, this conclusion retains its legitimacy, even taking into account the analysis of interfering factors, such vitapulse as body size and phylogeny (116.117). This observation is consistent with data showing that the goods oxidative damage (measured by the number 8OHdG) medina, but not nuclear DNA, inversely correlated with life expectancy (118.119); but in this case once again raises the question of the accuracy of the methodology. Direct evidence of the importance vitapulse of mitochondrial ROS production to aging of mammalian animal models have provided - genetically modified mice expressing human catalase, the selective action in peroxisomes, mitochondria or nuclei. Only the expression of catalase, the direction of action on mitochondria (MCAT-mouse), decreased the level of oxidative damage and causes a very significan vitapulse t increase in both the average and maximum life span (up to 21%) (120). In accordance with a causal role in the formation of the AFC de novo point mutation in vivo, in mice heart cells lines MCAT accumulated 50% less medina point mutations vitapulse than wild-type cells of corresponding age animals (Fig. 1) (64). In contrast to the proof of approval obtained in experiments on line MCAT mice heterozygous knockout mice MN SOD / - showed no phenotypes relevant premature aging, despite elevated levels in 8OHdG Nina and medina (121). In these animals, however, there was an increased incidence of malignant diseases and to date it is unclear whether they have observed an increased number of mtDNA mutations. Like it? Share it! |