CDX model

Posted by Catalina Garcia on April 13th, 2024

Cell Line Derived Tumor Xenograft (CDX) Mouse Models

As a vital step in the process of antineoplastic agent discovery, cell line derived tumor xenograft (CDX) models are widely used for preclinical test of drug efficacy, PK/PD correlation, and combination therapy. Human tumor cell line xenografts establish tumors when implanted in immunodeficient mouse. In this kind of model, it's feasible to investigate the efficacy of novel agents in inhibiting tumor growth and development as well as the mechanisms of action.

Although implanting human tumors directly into mice is gradually popular in anti-tumor drug discovery due to their accurate recapitulation of patient tumor features, CDX models are still proved practically to be an efficient method for in vivo study in terms of their excellent repeatability.

Establishment of CDX Mouse Models

CDX models are based on a variety of tumor cell lines that are easy to grow in culture and rapidly form tumors after inoculation into immunodeficient mice. The cells may be implanted subcutaneously, intravenously or orthotopically to induce tumors in different microenvironments.