Today’s generation expect fast results. So treatment with medicines is the best option for them. The class of drugs known as phosphodiesterase type 5 inhibitors (PDE-5 inhibitors) are most commonly prescribed medicines for treating erectile dysfunction.
Zenegra and its active component
Zenegra is a potent PDE-5 inhibitor used for treating ED. It is a generic equivalent of the brand Viagra. It contains Sildenafil Citrate as the active pharmaceutical component, which was the first effective oral drug approved by the Food and Drug Administration (FDA) in the year 1998 for treating ED. Zenegra is not sold without prescription. Zenegra is manufactured by a special technique of reverse engineering of the active constituent Sildenafil Citrate.
The most commonly prescribed dose is 100mg once daily. Do not exceed the dose and duration of treatment than recommended by doctor. There should be a gap of 24 hours between two doses. Take this medicine with a glass of water about 30 to 60 minutes prior to sexual intercouse.Do not chew, crush or split the tablet.
Mechanism of Action
The enzyme PDE-5 is abundantly present inside penis. The concentration of the enzyme cGMP in the penis is elevated by inhibiting its degradation by PDE-5 enzyme. The function of cGMP in the penis is relaxation of smooth muscles and dilation of the blood vessels. The dilated blood vessels increase the blood supply to the penis which produces a firm and strong penile erection for penetration into the female vagina giving a complete sexual satisfaction and complete sexual pleasure.
Onset of Action and Duration of Effect
The effect of this medicine is seen within half an hour to 2 hours after oral administration. The onset of action varies from person to person. The effect of this medicine continues for an average duration of 4 hours.
Warnings and precautions
Do not drive or operate machinery as these activities need high degree of mental alertness. If a person suffers from an overdose, call your physician immediately. Take the missed dose as soon as you remember. Skip the missed dose if it’s time to take next scheduled dose. Do not take two doses to compensate for a missed dose. This medicine is contraindicated in pregnant women, nursing mothers and men below 18 years of age. Concomitant use of Zenegra with alcohol, tobacco, grapefruit products, nitrates, alpha-blockers, other PDE- 5 inhibitors, fatty meals and Zenegra should be avoided.
Common side effects of this medicine include pain in head, back and muscle pain, vision disturbances, indigestion, flushing, nasal congestion, nausea, drowsiness and skin rash.
Severe side effects of Zenegra include chest pain, sudden hearing loss, and sudden vision loss, difficulty in breathing, irregular heartbeats, swelling of face, lips and tongue, prolonged and painful erection for more than four hours.