GW-501516

Posted by Thomas Shaw on October 5th, 2018

What it's:

GW501516 (GW1516 or GSK-516) is actually a drug that acts as a PPARd modulator. GW 501516 activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue, and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome, probably by stimulating fatty acid oxidation. It has been proposed as a potential remedy for obesity and related conditions, particularly when applied in conjunction having a synergistic compound AICAR, as the combination has been shown to significantly increase exercise endurance in animal research. Get extra information about this review

How it performs:

GW501516 can be a selective agonist (activator) of the PPARd receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARd with > 1000 fold selectivity over PPARa and PPAR?.

In rats, binding of GW501516 to PPARd recruits the co activator PGC-1a. The PPARd/coactivator complicated in turn up regulates the expression of proteins involved in power expenditure. Furthermore in rats treated with GW501516, elevated fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 enhanced high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL). The mechanism by which PPARd agonists raise HDL appears to become a result of elevated expression on the cholesterol transporter ABCA1.

Utilizes:

You can find two most important uses with GW-501516. The first and most typical use is that of elevated endurance. GW has been banned for specialist athletes as a result of unfair benefit it supplies to endurance athletes. Everyone want a drastic boost in endurance will discover that GW actually shines within this aspect. It takes effect quite quickly along with the final results could be staggering. A common dose of 10 mg day will supply a significant improve in endurance.

The second popular usage with GW is that of fat loss. A lot of users turn to GW as it has shown to melt off fat when nevertheless becoming non-catabolic. You'll find that you could still hold on to some muscle as that you are losing fat. It aids when you are operating it in conjunction with SARMS Ostarine and S4, to hold on to as considerably muscle as possible. A dosage of 10 mg each day will present excellent amounts of fat loss, but an increase to 20 mg per day will present a lot more within this area.

GW 501516 could be ran in 8 week cycles, but as with any other steroid or supplement, it need to be cycled appropriately to prevent any possible negative effects and the preserve it as successful as you possibly can.