A brief talk on the Fluconazole

Posted by beauty33 on February 26th, 2019

In recent years, the number of cases of ocular fungal infections has been increasing, but the diagnosis and treatment of this symptom is more difficult. Most of the drugs (such as amphotericin B) for ocular fungal infections are difficult to be widely used in clinical treatment of ocular diseases because of their high toxicity, and some drugs with relatively low toxicity. (e.g. miconazole, ketoconazole, etc.) can not be widely used because of the uncertainty of its therapeutic effect. Fluconazole has low toxicity, is soluble in water, is widely distributed and difficult to combine with plasma ribonuclease molecules, not only oral but also intravenous injection into the body lesion site. After the emergence of this drug has attracted the attention of the entire medical profession, and took the lead in foreign medical undertakings have been more widely used. Clinical studies have also shown that fluconazole is effective in the treatment of other diseases, such as ball-holding disease, and has gradually become the primary drug for the treatment of clinical eye diseases because of its low cost and safety. The study of fluconazole in the treatment of clinical ophthalmic diseases has also made remarkable achievements.

Fluconazole is a broad-spectrum antifungal drug for the treatment of fungal infections in humans and animals. There are tablets, capsules, powder injections and injection forms on the market at present. Fluconazole is a synthetic antifungal drug with triazole ring. It has broad-spectrum antifungal effect and is effective against deep and superficial fungal infections. It is widely used in clinic because of its 10-20 times stronger antimicrobial activity to vaginal Candida and some epidermal fungi than ketoconazole. With extensive application, the reports of adverse reactions are also increasing. Therefore, understanding the general rules and characteristics of adverse reactions of fluconazole has important guiding significance for clinical use.

The most common adverse reactions to fluconazole are allergic reactions. Because fluconazole as a apase can produce allergic reactions and cross-allergic to other triazole drugs, fluconazole and its inactive components or other azole drugs should be banned in patients with allergy. Pharmacokinetic characteristics showed that fluconazole was mainly excreted through the kidney, 80% of which was excreted with urine as a prototype. The elimination half-life was 27-37 hours. The half-life of fluconazole was significantly prolonged to 100 hours when the renal function was decreased. Patients with renal dysfunction should adjust the dosage according to the situation. Otherwise, fluconazole was easy to cause accumulation poisoning, even for patients with normal renal function should be avoided. Dosage should be used to avoid adverse reactions such as alkaline phosphatase and lumbosacral pain. Fluconazole also has a small amount of metabolism in the liver, may occur transient elevation of serum aminotransferase, liver dysfunction, etc., but after discontinuation of fluconazole, its liver toxicity is usually reversible, so when using, especially long-term high-dose use, should be regularly carried out liver function tests, close observation of more serious liver damage, if There should be immediate withdrawal of support and liver protection.

To sum up, the use of fluconazole in the treatment of various inflammation has a significant effect, significantly better than the traditional treatment, high safety, low complications, low recurrence rate, low sequelae, it is worthy of reasonable promotion in clinical. The industrial enzyme production of the fluconazole is a complex access, so for more information, you can click here to visit our website.

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