Through the years, researchers studying the connection between momordica charantia and diabetes, glucose levels, glucose tolerance, hyperglycemia, hypoglycemia, etc. have noted the following:
o In 1981, "These results show that karela improves glucose tolerance in diabetes," was published in the British Medical Journal.
o In 1981, in the Journal of Natural Products, "A hypoglycemic peptide, polypeptide-p, has been isolated from fruit, seeds and tissue of momordica charantia...is a very effective hypoglycemic agent when administered subcutaneously to gerbils, langurs and humans."
o In 1985, at the Foundation for Diabetes Research in Edinburgh, it was discovered that the only momordica charantia negative effects in normal mice were improved glucose tolerance. In diabetic mice, "the degree of hyperglycemia was reduced by 50% after 5 hours.
o In 1986, in the Journal of Ethnopharmacology, "The juice of Momordica charantia was found to significantly improve glucose tolerance of 73% of patients investigated.
o In 1988 at the Department of Biochemistry in Asarva, India, it absolutely was discovered that alongside lowering blood sugar, positive momordica charantia negative effects included delayed formation of diabetic cataracts in an animal study. A later study in 2002 confirmed these results.
o In 1993, a study concerning momordica charantia negative effects indicates that there's no hypoglycemic affect in non-diabetic controls, food intake is normal, growth and weight are normal, i.e. no negative side effects.
Involving the years of 1989 and 2006, there has been at the very least 40 different animal studies just like the ones mentioned above concerning momordica charantia and diabetes control, all with positive results. As the years have gone by, focus has shifted from if it works to how it works and what is the appropriate dosage. In the latest published research, in 2007, scientists asked for extra large scale placebo controlled clinical trials. If these studies can become a the truth is unknown, but is unlikely, because the plant extract is already widely available in non-prescription dietary supplements.
Additional positive momordica charantia side effects that have been noted over the years include lowering total cholesterol, protecting the kidneys and other organs from damage through anti-oxidant activity, stimulating amino acid uptake into muscles, improving energy and improving appetite. Researchers have mentioned that momordica charantia may "favorably impact the aging process ".
In Ayurvedic Medicine, it might be referred to as plant insulin. Scientific evaluation has confirmed the presence of a protein just like bovine insulin and that, in the laboratory; it "acts" like insulin.