Metamizole's latest usage and dosage description in the EU and other developed C

Posted by Manufacturer on March 10th, 2019

New instructions on the use and dosage of the painkiller Metamizole

The European Medicines Agency (EMA) recommends that the dose of Metamizole should be used consistently during pregnancy and lactation in all EU member states. This need stems from obvious differences and inconsistencies in the drug directives of several EU countries, as the drug occasionally causes serious side effects.


Specifically, the EMA has reviewed the human use (CHMP) for pharmaceutical products and recommends a uniform contraindication for daily maximum doses of pregnancy and lactation in the European Union. Metamizole is an analgesic that can treat severe pain and fever while other treatments are beyond control.

Recommended usage and dosage

The EMA defined a maximum dose as 1000 mg to 4 times a day, ie a maximum dose of 4000 mg per day, orally. For patients aged 15 years and older, treatment should start with the recommended minimum dose and only increase when needed. The injection dose should not exceed 5000 mg.

Young patients should be dosed based on body weight, but some products may not be suitable due to their effectiveness. For pregnancy and breastfeeding, a one-time dose is acceptable during the first 6 months of pregnancy, only if other analgesics are not available. But the drug should not be used during the last trimester of pregnancy due to the circulation and function of the kidneys of the fetus.

The Metamizole USA should not be used during breastfeeding because the baby can get a high amount of protein related to its weight.

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