Introduction to Some IL AntibodiesPosted by beauty33 on March 13th, 2019 Today let us learn some antibodies about IL.
Recombinant monoclonal antibody to Human IL1 beta. Canakinumab (INN, trade name Ilaris, previously ACZ885) is a human monoclonal antibody targeted at interleukin-1 beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha. Canakinumab was for the treatment of rheumatoid arthritis. Canakinumab is as a possible treatment for chronic obstructive pulmonary disease, gout and coronary artery disease. IL-1 Interleukin-1 (IL-1) is also known as lymphocyte stimulating factor. It is mainly produced by activated mononuclear-macrophages IL-5 Structure: IL-5 is produced by CD4 + T cells activated by antigen, and mast cells can also produce IL-5. The molecular weight of natural IL-5 is 40-50KD, which is a dimer glycoprotein linked by disulfide bond, but the monomer IL-5 also has IL-5 activity.
Sarilumab is a recombinant human monoclonal antibody expressed in CHO binding to human IL6. Anti-Human IL6 Therapeutic Antibody is a human monoclonal antibody against the interleukin-6 receptor for the treatment of rheumatoid arthritis. IL-6 Structure: Human IL-6 gene is located on chromosome 7, and the molecular weight of IL-6 is between 21 and 30 KD. Function: Monocyte macrophages, Th2 cells, vascular endothelial cells and fibroblasts are the main products. It can stimulate the proliferation of activated B cells, secrete antibodies, stimulate T cell proliferation and CTL activation, stimulate hepatocytes to synthesize acute phase proteins, participate in inflammatory response, and promote the development of blood cells. IL-6 can be synthesized by a variety of cells, including activated T and B cells, monocytes-macrophages, endothelial cells, epithelial cells and fibroblasts.
Recombinant monoclonal antibody to IL12+IL23. Ustekinumab (INN, experimental name CNTO 1275, proprietary commercial name Stelara, Centocor) is a human monoclonal antibody. It is directed against interleukin 12 and interleukin 23, naturally occurring proteins that regulate the immune system and immune-mediated inflammatory disorders. IL-12 Structure: IL-12 is mainly produced by B cells and macrophages. Its molecule is a heterodimer. Two subunits of 40 KD (p40) and 35 KD (p35) are linked by disulfide bonds. IL-13 Structure: IL-13 is produced by TH2 cells and its molecular weight is about 10 KD. Functions: IL-13 can induce the differentiation of monocytes and enhance the expression of MHC class II molecules; inhibit the secretion of monocyte factors induced by LPS and control inflammation; induce the proliferation of B cells and synthesis of IgE antibodies, enhance the expression of MHC class II molecules, CD23 and CD72 on the surface of B cells; cooperate with IL-2 to stimulate the production of IFN by NK cells, thereby promoting the activation of monocyte-macrophage and the immune response of TH1 cells. Recently, it has been found that IL-13 also has many functions, such as inhibiting HIV-1 replication in macrophages, inducing IL-1RA gene expression and protein synthesis in neutrophils.
Recombinant Humanized (from mouse) antibody to Human IL17A. Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis. It binds to IL17A and acts as an immunomodulator. IL-17 Function: IL-17 is the main effector of Th17 cells. It is secreted by CD4 + T cells. It can induce the synthesis and secretion of IL-6, IL-8, G-CSF and PGE2 by epithelial cells, endothelial cells and fibroblasts, and promote the expression of ICAM-1. Like it? Share it! More by this author |