Posted by freemexy on July 4th, 2019
PR171 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase). In vitro study has shown that NCM-0846 blocks Wnt signaling and exhibits remarkable anti-tumor and anti-CSC activities. In vivo study has also confirmed that NCB-0846 can inhibit Wnt-driven intestinal tumorigenesis in Apc min/+ mice and the sphere- and tumor-forming activities of colorectal cancer cells. NCB-0846 causes a dose-dependent reduction of the multiplicity and dimensions of tumors that developed in the small intestine. It also significantly suppresses the growth of the PDXs (patient-derived xenografts) established from the two patients in two more clinically relevant mouse models. Therefore, NCM-0846 has the potential to become a useful therapeutic method for tumor treatment.
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