Something You Must Know About Adipokine

Posted by Nancy Murray on July 31st, 2019

Adipose tissue is traditionally considered to be an inert tissue, mainly used to store fat, provide energy and insulation, absorb shock, regulate body temperature, fill and fix, etc. Adipose tissue can secrete a variety of bioactive substances, such as leptin, adiponectin and Interleukin 6 (IL-6), which are called adipokine because they are widely affected by adipose tissue secretion and regulation of body energy metabolism. However, adipose tissue is not only a mechanism for storing excess energy but also an active endocrine organ. Adipokine plays an important role in obesity, cardiovascular disease, immune response, and blood glucose regulation.

As we all know, obesity has become a global health problem, which can aggravate a variety of cardiovascular diseases, such as hypertension and coronary heart disease. As an important endocrine organ, adipose tissue secretes a variety of adipokines that can participate in or regulate the occurrence and development of cardiovascular diseases. There are many factors cause obesity, but the main reason is that energy intake is greater than energy consumption, and excessive energy intake is converted into fat storage, resulting in obesity. According to a leading medical journal, the global number of fat people exceeds that of thin people, and the prevalence of overweight /obesity among adults has increased from 13.4% to 26.4%. Obesity not only affects people's physical beauty and health, but also is a potential risk factor for cardiovascular diseases and tumors such as diabetes, hypertension, and atherosclerosis. Therefore, the problem of obesity should not be underestimated and must be taken seriously.

And Leptin is the most widely studied at present, and the role of leptin in weight regulation has been widely recognized. The involvement of adipokines in brain structure and function has a certain impact on brain-related cognition and aging. It is a substance secreted by human tissue, which can reduce body weight, store glucose, inhibit appetite, increase energy consumption and promote the decomposition of fat. Meanwhile, it was found that the concentration of serum leptin was positively correlated with body fat weight and body weight, and the increase in body weight was mainly caused by the increase in fat content. Although the level of serum leptin in obese people is very high, high levels of leptin have lost the effect of inhibiting feeding. Leptin resistance is a phenomenon in which the body is not responsive to or sensitive to leptin, showing signs of exuberant appetite, reduced energy consumption, and obesity. Therefore, it is undeniable that leptin resistance is one of the important causes of obesity.

Also besides, as a specific adipose factor, adiponectin is a special protein with a variety of biological effects, which is secreted by adipocytes. It can be involved in regulating blood lipid metabolism, improving hyperglycemia, reducing the degree of obesity, and inhibiting the production and release of TNF, which has a certain anti-inflammatory effect and is of great benefit to weight loss. Adiponectin reduces weight mainly by stimulating energy consumption. Adiponectin levels increase in obese patients after their weight loss. Therefore, increasing the adiponectin content is beneficial to the exploration of the pathogenesis and prevention of diabetes, and has positive significance for the prevention and relief of cardiovascular disease.

Hence it can be seen from the above analysis that adipokines play an immeasurable role in human health and disease treatment. Through the analysis of the rich variety of adipokines, we learn that any substance has two sides, but with the development of science and technology and the progress of biomedicine, many substances that people usually think are not beneficial to the human body often have unique benefits. For example, the categories of adipokines mentioned above are of positive significance for the prevention and treatment of obesity, cardiovascular disease, and diabetes. The development of research for adipokine still has a long way to go. However, with the rapid development of biotechnology and the unremitting efforts of researchers, the application prospect of adipokine is bound to be broader.

And, what else can we learn?

As a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents, Creative Diagnostics has built a mature production service system for adipokine and have perfect SOPs for efficient implementation. And it has achieved good technical support, sells well in many places and enjoys a high reputation in the industry.

For additional information. Please contact:

Email: contact@creative-diagnostics.com

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