Stem Cell—A New Hope to Medical Area

Posted by Jerry Carter on September 25th, 2019

"Stem cells are the most important life resources of human beings."—Head of Creative Biolabs

Overview of Stem Cells

Stem cells, characterized by infinite or immortal self-renewal capacity, have the competence of producing at least one type of highly differentiated progeny cells, bringing tremendous benefits in the field of medical therapy to human beings. According to different differentiation potential, stem cells can be divided into pluripotent stem cells, totipotent stem cells and monopotent stem cells.

Benefits from High-tech Advancement

The scientific community unanimously acknowledges that the 21st century is an epoch when biotechnology plays a dominant role in science and social economy, which directly affects human life, social and economic development. In the field of biotechnology, stem cell therapy (SCT) and stem cell engineering are the most concerned disciplines, whose common characteristics lie in that they bring infinite benefits to human wholesomeness and longevity. Many big CRO companies emerge holding the regarding technologies to support stem cell therapy projects, among which Creative Biolabs has been regarded as the pioneer.

Of all the stem cells produced by the human body, the pluripotent stem cells are receiving increasing focus as their character of self-renewal and differentiation to form any type of cells, and their differentiation potential to form a complete individual, such as embryonic stem cells.

Solutions of Induced Pluripotent Stem Cells (iPSC) from Creative Biolabs

The workflow composes iPSC reprogramming, iPSC culture, pluripotent characterization, iPSC genome editing and iPSC differentiation.

1.  Techniques adopted in the reprogramming methods are 2 mainly, chemical and transgene reprogramming, for quick and high-quality iPSC generation with comprehensive viral vectors, DNA, RNA and other designed proteins.

2.  Culturing the iPSC mainly covers maintenance, 3D culture and scale-up culture, of which the factors like growth medium, extracellular components and environmental cues must be paid attention to.

3.  Approaches to iPSC pluripotency characterization rely on RNA extraction, cDNA transcription, polymerase chain reaction, and immunofluorescence staining which are based upon the advanced iPSC platform, to ensure the characterization result worth the expectations. The extensions of the procedure include but are unlimited to iPSC morphology, teratoma formation assays, karyotype analysis, gender determination and so on.

4.  Genome editing solutions are indispensable, composing gene knock-out, insertion, mutation, correction or replacement, induced expression or over expression.

5.  Last but not the least procedure of delivering the induced pluripotent stem cells is differentiation, to diverge the produced iPSC into neuronal cells, hepatocytes, cardiomyocytes, ocular cells, blood cells and so forth, so that the results can meet different research or other purposes.

Application Prospects

Stem cell researches have attracted widespread attention throughout the world, which have broad application prospects in the fields of life science, developmental biology, pharmacology, etc.

• As seed cells of cell therapy and tissue organ replacement therapy
• Exploring the regulation mechanism of embryonic development
• As a vector for gene therapy
• Integrating exogenous genes in vitro to study gene function
• Establishing of drug screening Platform, pharmacological research and new drug development

About the Company

With years’ experience in providing high-quality products and one-stop solutions in the field of biopharmaceuticals for global clients, scientists in Creative Biolabs will be more focused to meet the need for stem cell therapy development.