Superlist Name:N-Methyl-D-Aspartic Acid powder
CAS No.: 6384-92-5
Synonyms:(R)-2-(Methylamino)succinic acid; NMDA
N-Methyl-D-Aspartic acid (NMDA) is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in 1960s. N-Methyl-D-Aspartic acid (NMDA) is an excitotoxin(it kills nerve cells by over-exciting them); this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term "lesion studies."
Researchers apply N-Methyl-D-Aspartic acid (NMDA) to specific regions of an (animal) subject's brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior. If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior