Compound 7P (CAS No.:1890208-58-8)

Posted by freemexy on October 29th, 2019

Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves pharmacological manipulation of implicated signaling pathways. Compound 7P
As report from Journal of medicinal chemistry shows compound 7p which promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration in vivo. further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis for future efforts to enhance treatment strategies.

Compound 7P basic information:

Name: Compound 7P
CAS No.:1890208-58-8
Chemical name:
2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide
2-[(2-Methoxyphenyl)[4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide
Molecular Formula: C22H23N3O5S
Molecular Weight: 441.508
Chemical Structure: