Systemic Drugs treat Severe Cases of Candidiasis

Posted by Deeksha on December 5th, 2019

Candidiasis is common infection that occurs in oral cavity. A slew of factors including dentures, prolonged antibiotics therapy, malnutrition, xerostomia, local trauma and endocrine disorders increase the chances of Candidiasis in different individuals as all the mentioned factors weaken the defense mechanism of the body. HIV patients are more likely to be infected by Candidiasis. An intelligence report titled, “Candidiasis-Pipeline Review, H2 2019” is the source of all the stated insights. This report is the latest addition to Market Research Hub’s ever growing repository.

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Diagnosis of Candidiasis is basically clinical and involves identification of lesions by any medical professionals. Various clinical procedures include cytological smear, biopsy and microorganism’s culture. The treatment involves various steps that include early and accurate diagnosis, correction of underlying diseases, evaluation of infection, administration of anti-fungal drugs and evaluation of toxicity. Determination of infection type is significant to determine the treatment.

Preventive Measures important

Patients are also directed to adopt preventive measures such as maintaining regular oral hygiene that involves cleaning of teeth, tongue and dentures. Dentures removal at night is presumed to be very good practice as it removes the biofilm layer that generates on the prosthetic surface.

Pharmacological treatment includes topical drugs and systemic drugs where the former treats superficial infections and the latter is applied for more severe infections. Nystatin has been used for treatment traditionally. They are preferred for their potential to be poorly absorbed in the intestine which results in anti-fungal excretion which reduces hepatotoxicity. Fluconazole is the other drug that is considered for treatment and studies are being carried out to determine its efficacy. Fluconazole oral suspension is presumed to bring better patient compliance as it involves only one dose daily.

Triazol antifungal voriconazole have surfaced as a potent drugs and more studies are carried out to assess its effectiveness. General treatment guidelines include two primary steps? using Hexetidine as antiseptic agent and removal of dentures at night.

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Candidiasis pipeline review, H2 2019: Report Synopsis

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