New Ideas for Alzheimer's Disease—Stem Cell Therapy Will Play an Important Role

Posted by Caroline91 on December 6th, 2019

The current aging population is on the rise, and the number of Alzheimer's disease (AD) worldwide is also increasing year by year. The main cause of AD is the deterioration of neuronal function, so how to maintain the function of degenerating neurons has become the focus of clinical problems, and stem cell therapy will play an important role.

New Treatment of Alzheimer's Disease

There is no definite cause of senile dementia, and medical studies indicate that Aβ deposition and excessive activation of tau protein lead to intracellular neurofibrillary tangles, partial deformation of temporo-parietal lobe and frontal lobe and cingulate gyrus, and neuronal damage and loss. Attempts to reduce Aβ deposition and tau overactivation have largely failed in clinical trials. So instead of focusing on maintaining and protecting neuronal function, we directly reduce inflammation and allow neurons to regenerate, so we should be more efficient in tapping the potential value of stem cells.

Stem Cell Therapy for Alzheimer's Disease:

1. Introduction of exogenous stem cells can effectively restore degenerated neuronal networks and cognitive functions. The role of stem cells is cell delivery to repair lesions.


2. Neural circuit regeneration is facilitated by the differentiation of stem cells.

Currently embryonic stem cells (ESCs), mesenchymal stem cells (MSCs), brain-derived neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs) are all included in the research for the treatment of Alzheimer's disease. Mesenchymal stem cells have been found to have high potential for the treatment of Alzheimer's disease, and both efficacy and safety have been confirmed by clinical trials. Mesenchymal stem cells not only facilitate in vitro expansion and culture, but also can effectively differentiate into a variety of cell tissues and organs, which is widely used. Through animal model experiments, mesenchymal cells can differentiate into nerve cells after transplantation, effectively increasing the concentration of local acetylcholine neurotransmitter, brain-derived neurotrophic factor and nerve growth factor, and improving both motor and cognitive functions.

The Future of Stem Cell Therapy for Alzheimer's Disease

Through preclinical and clinical experiments, stem cell transplantation in the treatment of Alzheimer's disease can not only regulate the environment of brain inflammation, but also promote nerve regeneration and synaptic connectivity, and can effectively improve the patient's condition. The safety of stem cell therapy can be obtained through human experiments. The future of stem cell therapy for Alzheimer's disease can be expected. Together, we expect more patients with Alzheimer's disease to control and effectively improve their condition. The topic of subversion of human life is no longer a problem in medical subjects.

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