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Posted by themorningwalk on July 7th, 2020

Both active ingredients of the Augmentin ® preparation - amoxicillin and clavulanic acid - are quickly and completely absorbed from the gastrointestinal tract after oral administration. The absorption of the active ingredients of the drug Augmentin ® is optimal in case of taking the drug at the beginning of a meal.

The pharmacokinetic parameters of amoxicillin and clavulanic acid obtained in different studies are shown below, when healthy volunteers aged 2-12 years on an empty stomach took 40 mg + 10 mg / kg / day of the drug Augmentin ®, powder for oral suspension, in three doses. click here to buy augmentin tablets 125 mg + 31.25 mg in 5 ml (156.25 mg).

Basic pharmacokinetic parameters

The pharmacokinetic parameters of amoxicillin and clavulanic acid obtained in different studies are shown below, when healthy volunteers aged 2–12 years old on an empty stomach took Augmentin ®, powder for oral suspension, 200 mg + 28.5 mg in 5 ml (228 , 5 mg) at a dose of 45 mg + 6.4 mg / kg / day, divided into two doses.

Basic pharmacokinetic parameters

Use in children

Children under 12 years of age - in the form of a suspension, syrup or drops for oral administration. A single dose is established depending on age: children up to 3 months - 30 mg / kg / day in 2 divided doses; 3 months and older - for infections of mild severity - 25 mg / kg / day in 2 divided doses or 20 mg / kg / day in 3 divided doses, for severe infections - 45 mg / kg / daily in 2 divided doses or 40 mg / kg / day in 3 divided doses. The maximum daily dose of amoxicillin for children under 12 years old is 45 mg / kg body weight. The maximum daily dose of clavulanic acid for children under 12 years old is 10 mg / kg body weight.

Augmentin use: special instructions

First of all, I would like to emphasize that Augmentin is the gold standard in the treatment of diseases of the oropharynx, upper and lower respiratory tract, caused mainly by gram-positive microorganisms. http://www.drugs.com/dosage/augmentin-oral-suspension.html Moreover, the spectrum of the drug is so wide that it is able to cover almost all pathogenic microorganisms. Unfortunately, many therapists like to hide behind two or even three antibiotics. Often, vigilant doctors are reinsured in this way with outpatient and even inpatient treatment for pneumonia. As a result, the treatment regimen for uncomplicated pneumonia takes a “multi-storey look” and contains several antibiotics, including Augmentin. In this case, combinations of injectable and tablet forms of various antibacterial drugs look especially impressive.

Patients do not even suspect that correctly selected Augmentin does not require the addition of another antibiotic. The activity of Amoxicillin against Streptococcus pneumoniae (the main causative agent of pneumonia) is significantly higher than that of Ampicillin and Benzylpenicillin. Therefore, in the vast majority of cases of pneumonia caused by strains with intermediate sensitivity to Ampicillin and Benzylpenicillin, monotherapy with Augmentin.

In the treatment of infections of the urogenital tract (inflammation of the kidneys, bladder, pelvic organs), antibiotics of the fluoroquinolone series are still considered the drugs of choice. However, drugs of this group are contraindicated for use in children. Therefore, in pediatric practice, Augmentin can be used for such infections..

Also See: Divided Doses, Pharmacokinetic Parameters, Clavulanic Acid, 12 Years, Mg, Kg, Augmentin

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