Exosome Characterization Services to Better Define Characteristics of Exosome atPosted by Candy Swift on November 30th, 2020 Exosomes are membrane-bound extracellular vesicles containing biologically active proteins, RNAs and microRNAs. They are well known to participate in cells communication, and have been actively studied as potential clinical therapies. Recent research by scientist team of University of Alabama at Birmingham gives exosome more value by showing that exosomes produced from a mixture of heart muscle cells, endothelial cells and smooth muscle cells have regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells. More and more research is conducted to explore the functions and applications of exosomes, and with years of exploration in this field, Creative Biolabs has formulated a variety of protocols to better define the characteristics of exosome based on various technologies, thus to help global clients better define exosome characteristics and facilitate the downstream applications.
Creative Biolabs offers high-end nanoparticle tracking analysis-based exosome characterization, including nanoparticle tracking analysis and fluorescence nanoparticle tracking analysis. The former can accurately measure vesicle size and concentration, and the latter, also known as fl-NTA allows for accurate sizing, counting, and phenotyping of exosomes.
To better understand the characteristics of exosomes and facilitate the later therapeutic and diagnostic application, Creative Biolabs provides the detail size distribution and exosome concentration measurement based on the highly sensitive tunable resistive pulse sensing (TRPS) technology. The TRPS system is of high sensitivity and stability supported by whole-process technical trace service and direction of professional team.
Exosomal surface markers-based exosome characterization services at Creative Biolabs are supported by FACS, Western Blotting and ExoTEST (ELISA). The optimally configured FACS flow cytometer can analyse and sort exosomes based soley on the presence of endogenour membrane constituents. While western blotting is to identify and quantify a specific protein in a complex mixture. ExoTEST is a patented double sandwich ELISA assay for quantitative and qualitative analysis of exosomes.
Mass spectrometry (MS) is an analytical technique to ionize chemical species and sort the ions based on their mass-to-charge ratio. Based on the high sensitivity of MS technology, Creative Biolabs can provide accurate information of proteomic components of exosome, including qualitative, quantitative and targeted quantitative analysis of exosomal proteins. In addition, Creative Biolabs also provides other exosome-related services for drug delivery research since exosome-engineered peptides, proteins, or antibodies may be applied for precise drug and therapeutic nucleic acid delivery. More information can be found on https://www.creative-biolabs.com/exosome. About Creative Biolabs Empowered by leading technology and years of experience in biomedical science, Creative Biolabs focuses on offering a full range of exosome-related services and products. With more than a decade of exploration and expansion, Creative Biolabs is now known as a famous institute and experienced supplier in the biotech market, accomplishing numerous challenging projects for customers. Like it? Share it! More by this author |