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Joined: November 27th, 2018
Articles Posted: 164

Articles

Published 11 Days Ago
Unveiling the Microbial World by Understanding the Diversity and Impact of Microorganisms
In fact, studies have shown that all organisms have evolved from a single prokaryote or more commonly known as the Last Universal Common Ancestor (LUCA). Today, it has been estimated that there are about one trillion species of microorganisms in the worl

Published 11 Days Ago
Mastering Microbial Cultivation by Navigating Aerobic and Anaerobic Growth Challenges
Microorganisms have different growth requirements. When culturing them in the laboratory, it is essential to take note of these conditions because these are needed to be replicated in order to successfully grow microbial cultures in the laboratory. As men

Published 11 Days Ago
Exploring How RNC-RNA Sequencing Illuminates Translational Dynamics and Molecular Mechanisms
When a ribosome is affixed to the polypeptide (protein) it is making, the ribosome-nascent chain complex (RNC) is the compilation of molecules that make up the ribosome. One of several methods can be used to halt the synthesis of the nascent polypeptide.

Published 11 Days Ago
Sequencing Depth, Coverage and Read Types for NGS
Sequencing depth is the ratio of the total number of bases (bp) obtained by sequencing to the genome size, which is one of the indicators to evaluate the sequencing volume. There is a positive correlation between sequencing depth and genome coverage, and

Published 11 Days Ago
How to Choose ANOVA?
Analysis of variance (ANOVA) is a powerful statistical method that allows researchers to compare the means of two or more groups and determine if they are significantly different. It is a popular tool for testing hypotheses in a variety of fields in biolo

Published 11 Days Ago
How to Submit Sequence Data to GenBank
In addition to raw sequence data, you can also submit computationally assembled sequences, genomes, functional genomics data, microarray data, clinical data, genome variations, and other data types, such as PacBio methylation data. Submission to SRA, GEO,

Published 11 Days Ago
Advancements in Sequencing Technologies: Transforming Pathogen Detection and Clinical Diagnostic
Despite a multitude of microorganisms known to inflict human infections, prevailing diagnostic techniques merely scratch the surface, leaving a vast array of pathogens unidentified. This persistent challenge is further exacerbated by the continuous emerge

Published 2 Months Ago
Hybridization Capture and PCR Amplification: Comparing Two Key Enrichment Strategies in NGS
Amplicon-based approaches may be preferable for their simplified workflow and smaller amounts of required DNA. However, hybridization-based strategies are less likely to miss mutations and also perform better with respect to sequencing complexity and unif

Published 2 Months Ago
Targeting RNA Splicing: Mechanisms and Strategies
RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns).

Published 2 Months Ago
Comparative Analysis of Prime Editing and CRISPR-Cas9
CRISPR-Cas9 is a gene editing technology that has changed the landscape of biological research. It stands for Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-Associated Protein 9. CRISPR-Cas9 uses a two-component system consisting of

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