Articles By kiko

Published 3 Months Ago
What Is Single-Cell Sequencing and How to Achieve It?
The cell is the basic unit of life. Most current studies on the human genome, cancer or other fields are still conducted from the population level, and the results are often the mean value of gene expression in cell populations or only represent informati

Published 4 Months Ago
How Can MicroRNAs Contribute to Disease Research?
MicroRNAs (miRNAs) are non-coding RNAs containing 18-25 nucleotides encoded by endogenous genes and have the ability to regulate gene expression at the post-transcriptional level by repressing mRNA or promoting mRNA degradation. Typically, genes encoding

Published 4 Months Ago
What Can We Do with NGS for Oncology?
Gene sequencing is a type of genomic testing technology. PCR, fluorescence in situ hybridization (FISH) and microarray technologies are mainly used to investigate the presence or absence of specific fragment sequences through known genes, which focuses on

Published 4 Months Ago
How Does Hi-C Sequencing Capture the 3D Organization of Chromatin?
In recent years, with the development of linear genomes, researchers have used fluorescence in situ hybridization (FISH) and chromosome conformation capture (3C) to gain a deeper understanding of the three-dimensional (3D) conformation and content of chro

Published 5 Months Ago
The Relationship Between the Gut Microbiome and Drugs Is Greater Than We Thought
Gut microbes are considered "virtual organs" that influence host health and are involved in disease research. The human gut microbiota has a large gene pool, encoding approximately 100-150 times more genes than the human genome, and contains a rich resour

Published 5 Months Ago
SNP Array, A Powerful Tool for Diagnosis and Agrigenomics Research
Single-nucleotide polymorphisms (SNPs) are a kind of DNA polymorphisms caused by single-nucleotide variants in both coding and non-coding regions, which are the most common and smallest variants. There are more than 3 million SNPs in the human genome with

Published 5 Months Ago
Long Read Sequencing Fills in the Missing Pieces of Genomics
The development of DNA sequencing technology has made it possible for human beings to explore the mysteries of themselves and other beings, while the advent of the genomics era has put higher demands on sequencing technologies. Scientific research has now

Published 5 Months Ago
Epigenomics: Opening the Black Box of Cancer
The epigenome is composed of chemical markers and proteins that can attach to DNA and direct the function of gene regulatory elements, controlling the production of proteins in specific cells, among other roles.

Published 7 Months Ago
CD Genomics Perspective: NGS-Based Gene Panels for Cancer Research
Tumorigenesis involves in many somatic mutations, most of which are random. Generally, hundreds of genes are thought to be associated with oncogenesis progression and have high mutation rates. Digging deeper into the cancer genome can help to understand t

Published 7 Months Ago
CD Genomics Perspective: Bioinformatic Analysis for HLA Genotyping
Human leukocyte antigen (HLA) is a 3.6 Mb segment on the short arm of chromosome 6 that contains over 200 genes. It is also known as the major histocompatibility complex (MHC), and it is the most polymorphic region in the human genome, involving diverse i

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