Articles By kiko

Published 9 Months Ago
ATAC-Seq: Introduction, Features, Workflow, and Applications
Gene transcription requires the unraveling of a higher structural part of the DNA. This part of the chromatin is called accessible chromatin region and this process is achieved mainly by the modification of chromosomal histones (especially acetylation).

Published 9 Months Ago
Integrated ATAC, ChIP, HiC and RNA Sequencing Shed Light on the Chromatin Interactions Puzzle
The chromatin microenvironment is a dynamically balanced system of organismal epigenetic regulation and thus regulation of gene expression. Any heritable modification mechanism in the chromatin can be used as a marker of epigenetic inheritance. The dynami

Published 9 Months Ago
How to Identify Gene Promoters and Enhancers by ChIP-Seq
Chromatin immunoprecipitation (ChIP) is an effective method for isolating DNA fragments bound to specific proteins in vivo. DNA-binding proteins can be transcription factors (TFs) or other chromatin-associated proteins, such as histones. With the rapid de

Published 10 Months Ago
Unraveling the Genetic Code: An Introduction to Genome-Wide Association Studies
A genome-wide association study is what the National Institutes of Health call "a study of common genetic variation across the whole human genome with the goal of finding genetic links to observable traits.

Published 10 Months Ago
Exploring the Potential of RNA-Seq in Various Fields
Regulation of gene expression is fundamental to linking genotypes with phenotypes. RNAs shape complex gene expression networks, which drive biological processes. An in-depth understanding of the underlying mechanisms of how to govern these complex gene ex

Published 10 Months Ago
Bioinformatics Analysis of Small RNA Sequencing
Small RNAs are important functional molecules in organisms, which have three main categories: microRNA (miRNA), small interfering RNA (siRNA), and piwi-interacting RNA (piRNA). They are less than 200 nt in length and are often not translated into proteins

Published 10 Months Ago
How Whole Exome Sequencing Works: Principles and Workflow Demystified
As the development of biological experimental technology, especially gene-sequencing technology, both laboratory and clinical researchers realize that genome sequencing is the best way to analyze the etiology, pathophysiology, treatment and prognosis of d

Published 11 Months Ago
Advances in Targeted Region Enrichment Technologies
Whole genome sequencing looks at the whole genome of an organism, while targeted region sequencing looks at only the parts that are of interest. Targeted genome sequencing is a very sensitive and specific way to find SNPs, indels, CNVs, and large SVs.

Published 11 Months Ago
Evolutionary, Medical, and Clinical Applications of Whole Exome Sequencing
As we all know, proteins play important roles in human bodies since all physiologic events are related to the structural or mechanical functions of certain proteins. Studying the synthesis process of proteins is a way to study the etiology, pathophysiolog

Published 11 Months Ago
Navigating the Bioinformatics Workflow for Whole Exome Sequencing: A Step-by-Step Guide
Next-generation sequencing (NGS), which makes millions to billions of sequence reads at a fast rate, has greatly sped up genomics research. At the moment, Illumina, Ion Torrent/Life Technologies, 454/Roche, Pacific Bioscience, Nanopore, and GenapSys are a

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