Uric Acid In Blood: Causes And TroublesPosted by Carver Lundgren on May 27th, 2021 Now-a-days, those people, who are health conscious and select regular health check- up, are acquainted with the term "uric acid ".But most of them don't know what it really is and what kinds of problems it might create in the torso if it has excess of the acid. What is uric acid? From the nucleic acid of the living cells, by different metabolic processes, two substances called adenine and guanine are produced which are referred to as purine. Axit Uric in our body called xanthine-oxidase converts this purine, in three stages, to uric acid. Chemically, it consists of carbon, nitrogen, hydrogen and oxygen whose formula is C5H4N4O3. The salt of it is recognized as sodium urate monohydrate. Once the decay of cells occurs at a rate greater than the normal rate, then the forming of uric acid in the torso also increases. Axit Uric of it in the blood of a grownup male is 8mg/100ml of blood while that in a grownup female is 6mg/100ml of blood. If its level in the blood is more than the aforementioned maximum level, then it is called hyper-uricaemia, that is not a normal condition. It sometimes appears that generally its level in the blood increases gradually after 20 years and in the case of females this occurs, particularly, after the menopause. The full total content of the acid in the blood may remain within 900mg - 1200mg depending on the bodyweight, food habit and racial difference. 75% of it within our blood is excreted, unchanged, through urine, while 20 - 25% of it, changed somewhat, is excreted through the faeces. Uric acid inside our blood is in the proper execution of monosodium urate, which, if increases, gets deposited in the joints and kidneys and causes diseases. How does hyper-uricaemia occur? Hyper-uricaemia may occur due to a number of of the next reasons: 1) Increased formation of uric acid because of genetic characteristics or metabolic malfunctioning of enzymes. 2) Chronic kidney disease leading to less excretion of the acid through urine. 3) An excessive amount of intake of meat (lamb, beef) or sea-fishes. 4) Eating of fructose-rich foods. Sugar contains about 50% fructose. 5) Drinking of corn syrup. 6) Diseases causing rapid cell turnover, like polycythaemia, several types of leukaemia and a skin disease called psoriasis. 7) Drinking a lot of alcohol, particularly, beer. 8) Daily intake of very low dose of aspirin. An excessive amount of intake of tea or medicine containing caffein. 9) Thiazide like medicines which are accustomed to treat blood pressure and dropsy. 10) Medicines like pyrazinamide and ithambutol which are used to treat tuberculosis. 11) Medicines like livodopa, methyldopa, cysplatin and cyclomerine. 12) When a heavy person tries to lose excess weight quickly, then there occurs a rise in the uric acid level in his/her blood. 13) While doing excessive physical work or exercise, there's an elevated formation of lactic acid in the body. At that time, there may be a temporary increased production of uric acid in the blood. 14) Type 2 diabetes, high blood pressure, obesity, insulin-resistant disease syndrome'x'- in every one of these cases the level of the acid is high. Problems brought on by high uric acid level in blood This could cause mainly 2 kinds of diseases -- 1) Gout 2) Uric acid stone in kidneys Gout Gout arthritis is produced by increased uric acid level in the blood brought on by any disturbance in your body's purine or protein metabolism. Uric acid does not dissolve properly within our blood. So, any excess of it in the blood gets deposited inside our joints in the shape of monosodium urate crystals and causes inflammation. Gout is really a very painful disease of joints, which mainly occurs to aged persons. Males are 5-7 times more vulnerable to this disease compared to females. Axit Uric starts when the total amount of uric acid in the blood crosses its normal amount of 2-7mg/100ml. It sometimes appears that the painful apparent symptoms of gout arthritis start showing if this level in case of females exceeds 3.5-5mg/100ml and in case of males 5-7mg/100ml. Again, in case there is severe gout, the amount may be 20mg/100ml or more. Uric acid stone in kidneys When the amount of uric acid in the blood is very high, then the excess amount after saturation, which does not dissolve in blood, starts depositing in the kidneys, since 75% of the acid is excreted from the body through the kidneys. When the reaction of urine is acidic, then the kidneys cannot get rid of the complete of uric acid through urine. Moreover, during summer, when your body loses large amount of water or those people, who drink very less level of water, for them there's a possibility of easily developing stone in the kidneys. You can not feel any trouble at the first stage of kidney stone. Even, it can not be detected by ordinary X-ray or scan because the urate stone is radiolucent. It may be detected by sonography only.Like it? Share it! More by this author |