Uric Acid In Blood: Causes And TroublesPosted by Carver Lundgren on May 27th, 2021 Now-a-days, the individuals, who're health conscious and select regular health check- up, are acquainted with the phrase "uric acid ".But many don't understand what it really is and what kinds of problems it may create in the torso if it contains excess of the acid. What's uric acid? From the nucleic acid of the living cells, by different metabolic processes, two substances called adenine and guanine are produced which are called purine. An enzyme inside our body called xanthine-oxidase converts this purine, in three stages, to uric acid. Chemically, it consists of carbon, nitrogen, hydrogen and oxygen whose formula is C5H4N4O3. The salt of it is recognized as sodium urate monohydrate. When the decay of cells occurs at an interest rate greater compared to normal rate, then the forming of uric acid in the body also increases. The maximum permissible level of it in the blood of an adult male is 8mg/100ml of blood while that in a grown-up female is 6mg/100ml of blood. If its level in the blood is a lot more than the above maximum level, then it is called hyper-uricaemia, that is not a normal condition. It is observed that generally its level in the blood increases gradually after 20 years of age and in the case of females this occurs, particularly, after the menopause. Axit Uric of the acid in the blood may remain within 900mg - 1200mg with regards to the bodyweight, food habit and racial difference. 75% of it inside our blood is excreted, unchanged, through urine, while 20 - 25% of it, changed to some degree, is excreted through the faeces. Uric acid within our blood is in the proper execution of monosodium urate, which, if increases, gets deposited in the joints and kidneys and causes diseases. How can Axit Uric -uricaemia occur? Hyper-uricaemia may occur because of one or more of the next reasons: 1) Increased formation of uric acid as a result of genetic characteristics or metabolic malfunctioning of enzymes. 2) Chronic kidney disease leading to less excretion of the acid through urine. 3) An excessive amount of intake of meat (lamb, beef) or sea-fishes. 4) Eating of fructose-rich foods. Sugar contains about 50% fructose. 5) Drinking of corn syrup. 6) Diseases causing rapid cell turnover, like polycythaemia, various kinds of leukaemia and a skin disease called psoriasis. 7) Drinking too much alcohol, particularly, beer. 8) Daily intake of suprisingly low dose of aspirin. A lot of intake of tea or medicine containing caffein. 9) Thiazide like medicines which are accustomed to treat blood pressure and dropsy. 10) Medicines like pyrazinamide and ithambutol which are accustomed to treat tuberculosis. 11) Medicines like livodopa, methyldopa, cysplatin and cyclomerine. 12) When an obese person tries to lose excess weight quickly, then there occurs a growth in the uric acid level in his/her blood. 13) While doing excessive physical work or exercise, there is an elevated formation of lactic acid in the body. At that time, there can be a temporary increased production of uric acid in the blood. 14) Type 2 diabetes, high blood pressure, obesity, insulin-resistant disease syndrome'x'- in all these cases the amount of the acid is high. Problems due to high uric acid level in blood This might cause mainly 2 kinds of diseases -- 1) Gout 2) Uric acid stone in kidneys Gout Gout arthritis is created by increased uric acid level in the blood due to any disturbance in your body's purine or protein metabolism. Uric acid doesn't dissolve properly within our blood. So, any excess of it in the blood gets deposited within our joints in the shape of monosodium urate crystals and causes inflammation. Gout is just a very painful disease of joints, which mainly occurs to aged persons. Males are 5-7 times more susceptible to this disease compared to females. The issue starts when the total amount of uric acid in the blood crosses its normal degree of 2-7mg/100ml. It is observed that the painful apparent symptoms of gout arthritis start showing if this level in the event of females exceeds 3.5-5mg/100ml and in the case of males 5-7mg/100ml. Again, in case there is severe gout, the particular level may be 20mg/100ml or more. Uric acid stone in kidneys When the quantity of uric acid in the blood is quite high, then the excess amount after saturation, which does not dissolve in blood, starts depositing in the kidneys, since 75% of the acid is excreted from the human body through the kidneys. Once the result of urine is acidic, then your kidneys cannot dispose off the entire of uric acid through urine. Moreover, during summer, when the human body loses lot of water or those individuals, who drink very less quantity of water, for them there's possible of easily developing stone in the kidneys. It's possible to not feel any trouble at the very first stage of kidney stone. Even, it can not be detected by ordinary X-ray or scan since the urate stone is radiolucent. It could be detected by sonography only.Like it? Share it! More by this author |