Articles By kiko

Published 11 Months Ago
Exploring the Advantages of Low-Pass Whole Genome Sequencing
Low-pass whole genome sequencing refers to shallow whole genome sequencing, the process of sequencing an individual's genome at a lower depth, typically around 0.1x to 5x coverage, as compared to the standard depth of 30x to 50x in traditional whole genom

Published 11 Months Ago
Integrative Approaches in Pangenome Analysis for Genetic Understanding
During the long evolution of species, each individual has developed extremely specific genetic traits as a result of natural and anthropogenic selection, among other factors. In the classical view of intraspecific genetic variation, the genome of each ind

Published 11 Months Ago
Next-Generation Sequencing (NGS) Revolutionizes Pathogen Detection
Despite a multitude of microorganisms known to inflict human infections, prevailing diagnostic techniques merely scratch the surface, leaving a vast array of pathogens unidentified. This persistent challenge is further exacerbated by the continuous emerge

Published 1 Year Ago
Copy Number Variation Analysis
Currently, SNP arrays, short-read, and long-read-length genome sequencing are genome-wide high-throughput technologies that can be used to analyze CNVs in an individual's genome. Each of these technologies has its own limitations and advantages. Among the

Published 1 Year Ago
Principles and Key Concepts of Bioinformatics Experimental Design
A good experimental layout is essential for bioinformatics and data analysis. To begin, one must first evaluate the question that high throughput sequencing data is being used to answer. An experiment that is guided by a hypothesis will always be more inf

Published 1 Year Ago
Common File Formats in Bioinformatics
CD Genomics offers in-depth and comprehensive bioinformatics analysis services and supports the output and analysis of data in multiple file formats. The following are some of the most common file formats used in bioinformatics:

Published 1 Year Ago
Integrated ATAC, ChIP, HiC and RNA Sequencing
ATAC-seq technology is a technical approach to study nuclear chromatin with easy access to transposases using high-throughput sequencing. Highly active Tn5 transposase is used to insert sequencing junctions into open regions of chromatin, and sequencing o

Published 1 Year Ago
ATAC-Seq: Introduction, Features, Workflow, and Applications
By cleaving the open nuclear chromatin region at a specific space-time by transposase, we obtain the regulatory sequences of all active transcripts in the genome at that space-time, and then discover the key regulatory transcription factors by mining the

Published 1 Year Ago
Metagenome Sequencing vs. Viral Amplicon Sequencing: Choosing Effective Sequencing Methods for Monitoring Viral Mutation
The advent of high-throughput sequencing technology has orchestrated a paradigm shift in our capacity to detect and study novel coronaviruses and other viral pathogens. The decision between rapid detection and meticulous sequence assembly becomes a critic

Published 1 Year Ago
Viruses and Virome Sequencing
Viruses, these minuscule and seemingly simple structures, are garnering increasing attention from scientists worldwide. With their unique characteristics and profound impact on living organisms, viruses are a source of fascination and complexity that exte

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