sarms1 - Way to go for quality research chemicals

Posted by Darren Kearney on November 25th, 2019

SARMS1 sells Peptides and polypeptides and are are among the newer agents found in cosmetic products. Since they are often produced synthetically, they are mainly used in conventional cosmetics and less in natural cosmetics. Tests on cultured skin cells (in vitro tests) have for the first time demonstrated the effect of a peptide. Meanwhile, such tests are systematically performed by some companies to find new peptides with efficacy in different directions.

Many different active ingredient peptides on the market

The number of different peptides is large and it is constantly growing. What they all have in common is that they consist of amino acids, the building blocks of all organisms that make up proteins and enzymes. Generally, the peptides on the INCI are identified by the term "peptide," often with a number. Some important peptide drugs and their effects are briefly presented below.

Agireline

A peptide that has brought it to a certain notoriety, is the Agireline® with the INCI name Acetyl Hexapeptide 3. It is used as an active ingredient with "Botox-like effect" because it like the Botox to inhibit the contraction of the facial muscles. Of course, the effect of a cosmetic that still has to get through the skin, not nearly as strong, as for the well-known botulinum toxin. Because the botulinum toxin is injected directly under the skin during medical use. It may not be used as an active ingredient in cosmetic products. Nevertheless, a clinical study has shown that even a cream with Agireline® has a certain effect. It reduced wrinkle depth by 30%.

Other peptides

A similar effect as the Agireline possesses the active substance with the name Syn-ake® and the INCI name Dipeptide Diaminobutyroyl Benzylamide Diacetate. Syn-ake® reduced wrinkle depth and skin roughness after 28 days of use.

Other polypeptides with proven activity are:

• Palmitoyl Pentapeptide-4 leads to a decrease in wrinkle depth and wrinkle width.
• Tetrapeptide-21 leads to an increase in the synthesis of components of the extracellular matrix.
• Even natural peptides can work. Peptides extracted from rice and einkorn act synergistically with a hexapeptide on the wrinkle depth.

Conclusion: The peptides and polypeptides seem to have some effect. Often they are used to reduce the depth of wrinkles. But there are also other effects, such as peptides, which favorably influence the water content of the skin by improving the synthesis of water channels in the skin. Proof of action has been performed for certain peptides, but not to the extent that they are for established drugs such as vitamin C or vitamin A.