Articles By kiko

Published 1 Year Ago
Applications of Targeted Region Sequencing in Human Disease Studies and Clinical Care
Since the introduction of Sanger sequencing in 1977, genetic sequencing has been greatly improved with costs simultaneously falling. With the ability to rapidly produce large volumes of sequencing data, next-generation sequencing (NGS) enables researchers

Published 1 Year Ago
The Methods of Whole Genome Sequencing
The emergence of whole genome sequencing technology is a revolutionary advancement in all areas of life sciences. Whole genome sequencing can detect variants, including single-nucleotide variants, insertions/deletions, copy number changes, and large scale

Published 1 Year Ago
Detecting Fusion Transcripts by RNA Sequencing in Screening Tumors
A fusion gene is a chimeric gene formed by the fusion of partial sequences of two genes, usually due to chromosomal translocations or deletions. These chimeric genes can form abnormal transcripts or proteins in subsequent biological processes, which can l

Published 1 Year Ago
Degradome Sequencing: Introduction, Features, Workflow, and Applications
MicroRNAs (miRNAs) are a class of small endogenous non-coding RNAs of about 22 nt in length, with hairpin structures as precursors, which are widely found in animal, plant and viral organisms. Numerous studies have shown that miRNAs are involved in a wide

Published 1 Year Ago
Introduction to Aerobic and Anaerobic Culture
As mentioned in the previous article, one of the conditions needed to be taken into consideration is the oxygen requirement of the microorganisms. Some common microorganisms such as Escherichia coli and Bacillus sp. are usually cultured in the laboratory

Published 1 Year Ago
Microorganisms Fact Sheet: Definition, Types, and Importance
Microorganisms can be found everywhere, in the coldest or hottest environment, in the air, in water, in soil, in plants, and even inside the human body. These organisms have a big contribution to the ecosystem and to the biosphere as a whole.

Published 1 Year Ago
Blood RNA Sequencing: Introduction, Challenges, Workflow, and Applications
Considering that disease-causing and disease-protecting immune cells need to be transferred from lymphatic and secondary lymphoid organs through the peripheral circulation to their sites of action in disease, a clearer picture of the cells and their actio

Published 1 Year Ago
Integrated ATAC, ChIP, HiC and RNA Sequencing Shed Light on the Chromatin Interactions Puzzle
The chromatin microenvironment is a dynamically balanced system of organismal epigenetic regulation and thus regulation of gene expression. Any heritable modification mechanism in the chromatin can be used as a marker of epigenetic inheritance. The dynami

Published 1 Year Ago
How to Identify Gene Promoters and Enhancers by ChIP-Seq
Chromatin immunoprecipitation (ChIP) is an effective method for isolating DNA fragments bound to specific proteins in vivo. DNA-binding proteins can be transcription factors (TFs) or other chromatin-associated proteins, such as histones. With the rapid de

Published 1 Year Ago
Unraveling the Genetic Code: An Introduction to Genome-Wide Association Studies
A genome-wide association study is what the National Institutes of Health call "a study of common genetic variation across the whole human genome with the goal of finding genetic links to observable traits.

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