Articles By kiko

Published 1 Year Ago
Comparison Between Illumina and Nanopore Sequencing Technologies
Illumina sequencing is a second-generation sequencing technology that has become a powerful tool for genomics research. The method uses reversible dye terminator technology to detect the sequence of a DNA molecule. The process begins by fragmenting the DN

Published 1 Year Ago
Epitranscriptomic Modifications and How to Detect Them
RNA modifications, not limited to purine or pyrimidine bases, including N6-methyladenosine (m6A), 1-methyladenosine (m1A), 5-methylcytidine (m5C), 5-hydroxymethylcytidine (hm5C), 5-formylcytidine (f5C), 5-carboxycytidine (ca5C), inosine (I), pseudouridine

Published 1 Year Ago
How to Distinguish Bacteria and Fungi: From Morphology to Sequencing
When classifying bacteria and fungi, morphological features are v¬ery relevant. Colony morphology is a useful tool widely used to classify and define them by researchers. Carefully studied and used during these experiments are the colony properties of in

Published 1 Year Ago
Chimeric RNA and Sequencing Technologies: Advancing Detection and Research
Chimeric RNA, also known as fusion RNA, refers to RNA molecules that are formed as a result of the fusion of two or more different RNA transcripts. Chimeric RNA, a unique class of RNA molecules formed through various molecular mechanisms, such as trans-sp

Published 1 Year Ago
The Basics and Beyond of PacBio SMRT Sequencing
PacBio sequencing platform is a single-molecule real-time sequencing technology developed by Pacific Biosciences. PacBIo sequencing features long read length, high accuracy, uniform genome coverage, and detection of base modifications while sequencing.

Published 1 Year Ago
Unveiling Gene Isoforms by RNA Sequencing: Detection Methods and Applications
Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in the same organism or cell type but differ in their codin

Published 1 Year Ago
The Molecular Microbiology of SARS-CoV-2: Detection Methods and Infection Mechanism
SARS-CoV-2 is a newly discovered human coronavirus group (HCoV), which are single-stranded RNA viruses belonging to the family of Coronaviridae. A range of respiratory diseases have been induced by some of these pathogens in the past. SARS-CoV-1 infected

Published 1 Year Ago
Pan-Genome Analysis: Overview, Workflow, Application and Recent Advances
A pan-genome is the sum of all genomic information within a species. With the development of genomic technology, researchers have found that a single reference genome can no longer meet the needs of genomic data analysis, and more and more species, includ

Published 1 Year Ago
qPCR for SARS-CoV-2 Detection and Research: Introduction, Principles, and Applications
A highly delicate technique for the amplification and identification of deoxyribonucleic acid is polymerase chain reaction (PCR). In molecular biology, its conceptual simplification has made it the most utilized method and can, in theory, identify as litt

Published 1 Year Ago
RNA Splicing and How to Target It
RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions (exons) and non-coding regions (introns). RNA splicing

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